IRTG2403 - Regulatory Genome



AnnaAnna Monaco

Associated student

Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin-Mitte (BIMSB)
Hannoversche Str. 28
10115 Berlin, Germany


Email: AnnaAlessandra.Monaco[at]




Main Supervisor: Robert Zinzen

Duke partner: Michael Love




During my doctoral research project I aim to investigate how non-coding regulatory regions of the genome define the concerted spatio-temporal patterning of gene expression that leads to different cell types during development. The experimental design consists of a combination of wet lab sample preparation and computational approaches for data analysis. Understanding the regulatory evolution of cell identities and the contribution of transcriptional heterogeneity could pave the way to a better understanding of further biological questions, such as the rise of multicellularity or the genetic basis of human disease.